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KMID : 0861020230380050085
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Korea Journal of Herbology
2023 Volume.38 No. 5 p.85 ~ p.95
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Analysis of Chemical Components for Aerial and Underground Parts of Wild Ginseng and Evaluation of Skin Anti-aging Efficacy
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Roh Seok-Seon
Lee Gwang-Jin
Kim Byung-Hyun
Hwang Bo-Kyoung
Kim Hyo-Jin
Chang Yun-Hee
Yoou Jae-Kun
Ju Young-Sung
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Abstract
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Objectives : This study was intended to reveal the chemical profiles of aerial(leaf, stem) and underground(rhizome,
radix) parts of wild ginseng, and to investigate their anti-aging effects on human skin cells.
Methods : Wild ginseng, estimated for over 20 years, was divided into the aerial and underground parts. Total phenolic
contents of each extracts were measured using a Folin-ciocalteu method. The contents of 18 amino acids, 8 minerals
and 27 ginsenosides were determined by GC-FID, ICP-MS and LC-MS, respectively. The anti-aging effects, including
the radical scavenging activity, the activation of mitochondrial function on human fibroblasts, and the proliferation
activity on human keratinocyte progenitor cells, for the whole plant and underground part of wild ginseng were evaluated.
Results : The total phenolic acids, amino acids, and minerals in the aerial part were more than twice as high as in
the underground part. Compared to the cultivated ginseng root, there were various types of ginsenosides in both
parts of wild ginseng, and the total amount was more than twice as high. In particular, the aerial part significantly
contained ginsenoside F1, F2, C-Mc1, and C-O, and the distinctive patterns that distinguish each parts of wild
ginseng from the cultivated ginseng root were derived. The whole plant and underground part of wild ginseng exhibited
significant antioxidant effect(14.3-45.6%), activation of mitochondrial membrane potential(105.5-120.1%), and cell
proliferation(112.1-125.4%).
Conclusions : The entire plant and underground part of wild ginseng are high value-added plants and have beneficial
effects on skin anti-aging properties through its abundant metabolites.
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KEYWORD
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Wild Panax ginseng, Chemical components, Ginsenosides, Anti-aging effects
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